Completed
- Ancestral characterization of 1018 cell lines highlights disparities and reveals gene expression and mutual differences
Class Central Classrooms beta
YouTube playlists curated by Class Central.
Classroom Contents
The Biology of Health Disparities: Ancestry-Driven Drug Discovery - K. Sean Kimbro
Automatically move to the next video in the Classroom when playback concludes
- 1 - Introduction Julie Segre
- 2 - Start of Presentation K. Sean Kimbro
- 3 - About North Carolina Central University
- 4 - Kimbro Lab
- 5 - Migration and Forced Migration
- 6 - Unnatural Selection
- 7 - American Descendants of Enslaved Africans ADEA
- 8 - Protective Innate Immune Variants in Racial/Ethnic Disparities of Breast and Prostate Cancer
- 9 - Signatures of Environmental Genetic Adaptation Pinpoint Pathogens as the Main Selective Through Human Evolution
- 10 - IRA and TLR3 Sequence Variants May Alter Breast Cancer Risk Among African American Women
- 11 - Research Papers
- 12 - What would it look like to design drugs from a different perspective?
- 13 - 2020 Drug Trials Snapshot Summary Report
- 14 - Share of world population by major regions
- 15 - Race-based Drugs BIDIL
- 16 - Ancestral-Driven Drug Discovery
- 17 - Ancestral characterization of 1018 cell lines highlights disparities and reveals gene expression and mutual differences
- 18 - Genetic Ancestry Analysis Reveals Misclassification of Commonly Used Cancer Cell Lines
- 19 - New Approach: Addressing the Biology of Health Disparities by Targeting Geographical
- 20 - Molecular Profiling and Ancestral Proportions Triple Negative Breast Cancer TNBC Cell Lines
- 21 - The neuroendocrine mechanisms of chronic stress
- 22 - IC50s with Norepinephrine
- 23 - Increased circulating cytokine levels in African American women with obesity and elevated HbA1c
- 24 - Importance of Targeting IL-4 and IL-13 receptors for cancer therapy
- 25 - IL4/IL4R-activated signaling pathways that promote growth phenotypes
- 26 - Linear Map of IL4R
- 27 - IL4R Variants of Interest
- 28 - Acknowledgements
- 29 - Q&A Session
- 30 - Prevalence of selected innate immunity sequence variants in TNBC cell lines
- 31 - AlphaFold outputs for IL4R wt and variants
- 32 - Goal
- 33 - Things to think about
