ARDS - The "Real" Definition by Gordon Rubenfeld, MD M.Sc for OPENPediatrics

ARDS - The "Real" Definition by Gordon Rubenfeld, MD M.Sc for OPENPediatrics

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Intro

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1 of 12

Intro

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ARDS - The "Real" Definition by Gordon Rubenfeld, MD M.Sc for OPENPediatrics

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  1. 1 Intro
  2. 2 Outline
  3. 3 Everything we know about the ARDS clinical phenotype we learned in 1967
  4. 4 Syndromes are common in medicine and critical care
  5. 5 AECC definition Reliability and confusion
  6. 6 Everyone agrees we need a better ARDS definition but, what does better mean? • Reliability, Validity, Feasibility • How do you study validity without a gold standard?
  7. 7 Are direct (pulmonary) and indirect (extra-pulmonary) ARDS different?
  8. 8 Potential impact of recent changes in the definition of ARDS for clinical research
  9. 9 Berlin Draft Definition
  10. 10 Novel patient-level meta-analysis of 7 cohorts: 4 Clinical and 3 Physiological
  11. 11 Evaluation of Severe Ancilary variables identify a smaller group of patients with similar mortality 45% Mortality
  12. 12 A way forward - smarter biology latent class modeling for subphenotypes

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